Cold Spring Harbor Laboratory  
Contact Us | Faculty & Staff Directory
Tatiana Engel

Assistant Professor


PhD, Humboldt University of Berlin, Germany, 2007


Contact
This email address is being protected from spambots. You need JavaScript enabled to view it.
(516) 367-6902 (p)
 
My lab investigates how perception and cognition arise from changes in neural activity. We develop and apply computational methods to discover dynamic patterns in large-scale neural activity recordings. We then create mathematical models to explain how these activity changes emerge from signaling between neurons, ultimately driving behavior.
The brain’s activity is in constant motion: it ebbs and flows in big waves when we are in a deep slumber, turns into small ripples when we reawaken, and flows in orchestrated streams when we perceive, decide and remember. These complex dynamics are driven by intricate networks of microscopic interactions between hundreds thousands neurons and thus are only vaguely glimpsed in spike-trains of single neurons. Fortunately, recent advances in recording techniques enable us to monitor the activity of large neural populations in behaving animals, offering the opportunity to investigate how dynamic variations of collective neural-activity states translate into behavior. To gain insights from these large-scale recordings, we develop and apply computational methods for discovering collective neural dynamics from sparse, high-dimensional spike-train data. We also develop models and theory to explain how collective neural dynamics support specific network computations and how these dynamics are constrained by biophysical properties of neural circuits. In these endeavors, we employ and extend tools and ideas from diverse fields, including statistical mechanics, machine learning, dynamical systems theory, and information theory. Our work benefits from close collaborations with experimental neuroscience laboratories that are collecting neurophysiological data in animals engaged in sophisticated tasks, such as attention, decision making and learning.

Engel, T. A. and Steinmetz, N. A. and Gieselmann, M. A. and Thiele, A. and Moore, T. and Boahen, K. (2016) Selective modulation of cortical state during spatial attention. Science 354(6316) pp. 1140-1144.

Engel, T. A. and Chaisangmongkon, W. and Freedman, D. J. and Wang, X. J. (2015) Choice-correlated activity fluctuations underlie learning of neuronal category representation. Nat Commun 6pp. 6454.

Rading, M. M. and Engel, T. A. and Lipowsky, R. and Valleriani, A. (2011) Stationary Size Distributions of Growing Cells with Binary and Multiple Cell Division. Journal of Statistical Physics 145(1) pp. 1-22.

Engel, T. A. and Wang, X. J. (2011) Same or different? A neural circuit mechanism of similarity-based pattern match decision making. J Neurosci 31(19) pp. 6982-96.

Engel, T. and Andrieux, D. (2010) Forget before you remember: dynamic mechanism of memory decay and retrieval. Front Neurosci 4(3) pp. 3.

Additional materials of the author at
CSHL Institutional Repository